Mani S Kavuru Selected Research

Pulmonary Alveolar Proteinosis

9/2013	Alveolar macrophages of GM-CSF knockout mice exhibit mixed M1 and M2 phenotypes.
1/2013	Extracorporeal membrane oxygenation to support whole-lung lavage in pulmonary alveolar proteinosis: salvage of the drowned lungs.
6/2012	Rituximab therapy in pulmonary alveolar proteinosis improves alveolar macrophage lipid homeostasis.
1/2011	Restoration of PPARγ reverses lipid accumulation in alveolar macrophages of GM-CSF knockout mice.
6/2010	Targeted PPAR{gamma} deficiency in alveolar macrophages disrupts surfactant catabolism.
1/2009	A novel 1,25-dihydroxyvitamin D-activin A pathway in human alveolar macrophages is dysfunctional in patients with pulmonary alveolar proteinosis (PAP).
12/2007	ABCG1 is deficient in alveolar macrophages of GM-CSF knockout mice and patients with pulmonary alveolar proteinosis.
7/2006	An open-label trial of granulocyte macrophage colony stimulating factor therapy for moderate symptomatic pulmonary alveolar proteinosis.
2/2006	Suppression of activin A in autoimmune lung disease associated with anti-GM-CSF.
1/2006	Elevated gelatinase activity in pulmonary alveolar proteinosis: role of macrophage-colony stimulating factor.

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Mani S Kavuru Research Topics

Disease

18	Pulmonary Alveolar Proteinosis 09/2013 - 04/2002
13	Lung Diseases (Lung Disease) 09/2013 - 04/2002
10	Inflammation (Inflammations) 01/2012 - 12/2003
8	Asthma (Bronchial Asthma) 10/2010 - 07/2002
7	Autoimmune Diseases (Autoimmune Disease) 02/2006 - 04/2002
6	Sarcoidosis (Schaumann Disease) 01/2016 - 01/2004
3	Granuloma 12/2013 - 06/2006
2	Pneumonia (Pneumonitis) 10/2011 - 02/2004
2	Pulmonary Sarcoidosis 06/2006 - 01/2004
2	Rare Diseases (Rare Disease) 01/2004 - 10/2002
1	Graft vs Host Disease (Graft-Versus-Host Disease) 01/2016
1	Lung Neoplasms (Lung Cancer) 10/2014
1	Chronic Granulomatous Disease 12/2013
1	Respiratory Insufficiency (Respiratory Failure) 01/2013
1	Hypoxia (Hypoxemia) 01/2013
1	Obstructive Sleep Apnea 01/2012
1	Infections 10/2011
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 01/2006
1	Fibrosis (Cirrhosis) 01/2006
1	Airway Remodeling 09/2005
1	Eosinophilia 09/2005
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 02/2004
1	Arthritis (Polyarthritis) 01/2004
1	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2004
1	Platelet Glycoprotein IV Deficiency 12/2003
1	Interstitial Lung Diseases (Interstitial Lung Disease) 12/2003

Drug/Important Bio-Agent (IBA)

17	Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF)IBA 09/2013 - 04/2002
12	Surface-Active Agents (Surfactants)IBA 01/2011 - 04/2002
6	Proteins (Proteins, Gene)FDA Link 12/2013 - 04/2002
6	AutoantibodiesIBA 09/2013 - 10/2002
5	LipidsIBA 06/2012 - 12/2003
5	PPAR gammaIBA 01/2012 - 12/2003
5	CytokinesIBA 01/2012 - 07/2002
4	Transcription Factors (Transcription Factor)IBA 12/2013 - 12/2003
4	Phospholipids (Phosphatides)FDA LinkGeneric 01/2006 - 04/2002
3	Biomarkers (Surrogate Marker)IBA 10/2014 - 09/2005
3	Messenger RNA (mRNA)IBA 12/2013 - 06/2006
3	activin AIBA 09/2013 - 02/2006
2	Interferon-gamma (Interferon, gamma)IBA 01/2016 - 06/2006
2	Complement System Proteins (Complement)IBA 10/2014 - 09/2005
2	Carbon Nanotubes (Carbon Nanotube)IBA 12/2013 - 10/2011
2	Glucose (Dextrose)FDA LinkGeneric 01/2012 - 12/2003
2	Fluticasone (Cutivate)FDA LinkGeneric 10/2010 - 07/2006
2	CholesterolIBA 12/2007 - 12/2004
2	AllergensIBA 11/2005 - 07/2003
2	AntibodiesIBA 01/2005 - 12/2002
2	LigandsIBA 01/2004 - 12/2003
1	Interleukin-12 (IL 12)IBA 01/2016
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2016
1	Prednisone (Sone)FDA LinkGeneric 01/2016
1	salicylhydroxamic acid (SHAM)IBA 12/2013
1	Rituximab (Mabthera)FDA Link 06/2012
1	Calcitriol Receptors (Calcitriol Receptor)IBA 01/2012
1	CathelicidinsIBA 01/2012
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2012
1	Steroid Receptors (Steroid Receptor)IBA 01/2012
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2012
1	Cell Adhesion MoleculesIBA 10/2011
1	OsteopontinIBA 10/2011
1	Metalloproteases (Metalloproteinases)IBA 10/2011
1	Environmental Pollutants (Pollutants, Environmental)IBA 10/2011
1	CarbonIBA 10/2011
1	CollagenIBA 10/2010
1	montelukast (Singulair)FDA Link 10/2010
1	1,25-dihydroxyvitamin DIBA 01/2009
1	HLA-DQB1 antigen (HLA DQB1)IBA 05/2007
1	SteroidsIBA 07/2006
1	Adrenal Cortex Hormones (Corticosteroids)IBA 07/2006
1	Salmeterol Xinafoate (Serevent)FDA Link 07/2006
1	Fluticasone-Salmeterol Drug Combination (Advair)FDA Link 07/2006
1	gamma-AIBA 06/2006
1	Matrix Metalloproteinase 2 (Gelatinase A)IBA 01/2006
1	GelatinasesIBA 01/2006
1	Macrophage Colony-Stimulating FactorIBA 01/2006
1	PPAR-gamma AgonistsIBA 11/2005
1	Acute-Phase Proteins (Acute-Phase Protein)IBA 09/2005
1	Peptide Hydrolases (Proteases)FDA Link 09/2005
1	ChemokinesIBA 09/2005
1	Monocyte Chemoattractant ProteinsIBA 01/2005
1	Chemokine ReceptorsIBA 01/2005
1	cholestenoic acidIBA 12/2004
1	Omalizumab (Xolair)FDA Link 03/2004
1	Pharmaceutical PreparationsIBA 03/2004
1	LipopolysaccharidesIBA 02/2004
1	NF-kappa B (NF-kB)IBA 01/2004
1	Interleukin-10 (Interleukin 10)IBA 08/2003
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 07/2003
1	Indicators and Reagents (Reagents)IBA 10/2002
1	IgE Receptors (Fc epsilon RI)IBA 07/2002

Therapy/Procedure

8	Therapeutics 06/2012 - 04/2002
2	Plasmapheresis 01/2004 - 12/2002
1	Extracorporeal Membrane Oxygenation 01/2013
1	Lasers (Laser) 10/2011
1	Aftercare (After-Treatment) 10/2010
1	Nebulizers and Vaporizers (Inhaler) 07/2006